Class : Glycopeptides

Usage : Ticogrip is effective in threating Complicated skin and soft tissue , Bone and joint , Hospital acquired pneumonia,Community acquired pneumonia, Complicated urinary tract infections, Infective endocarditis, Peritonitis associated with continuous ambulatory peritoneal dialysis (CAPD), Bacteraemia that occurs in association with any of the indications listed above

Approved Indications : Complicated skin and soft tissue infections, Bone and joint infections, Hospital acquired pneumonia, Community acquired pneumonia, Complicated urinary tract infections, Infective endocarditis, Peritonitis associated with continuous ambulatory peritoneal dialysis (CAPD), Bacteraemia that occurs in association with any of the indications listed above

MoA : Teicoplanin inhibits the growth of susceptible organisms by interfering with cell-wall biosynthesis at a site different from that affected by beta-lactams. Peptidoglycan synthesis is blocked by specific binding to D-alanyl-D-alanine residues.

Method of Administration : Teicoplanin should be administered by the intravenous or intramuscular route. The intravenous injection may be administered either as a bolus over 3 to 5 minutes or as a 30-minute infusion.
Only the infusion method should be used in neonates.

Class : Polymyxins

Usage : INVISTIN is effective in treating Serious infections caused by Gram negative bacteria including LRTI, UTI when commonly used systemic antibacterial agents may be contraindicated or may be ineffective because of bacterial resistance, Post surgical infections in hospitalized patients, Neonatal sepsis, Nosocomial infections, & Ventilator –associated pneumonia (VAP)

Approved Indications : serious infections caused by Gram negative bacteria including LRTI, UTI when commonly used systemic antibacterial agents may be contraindicated or may be ineffective because of bacterial resistance, Post surgical infections in hospitalized patients, Neonatal sepsis, Nosocomial infections, Ventilator –associated pneumonia (VAP)

MoA : Colistimethate sodium is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Colistimethate is polycationic that works by damaging the cell membrane.This effect is bactericidal. Polymyxins are selective for gram negative bacteria that have hydrophobic outer membrane.

Method of Administration : Can be given as 50 ml IV infusion over 30 minutes

Class : Carbapenems

Usage : Envade is effective in treating lower respiratory tract infections, Urinary tract infections , Intra-abdominal infections, Gynecological infections, Life-threatening infections (Septicemia, Endocarditis, Shock), Bone and joint infections, Polymicrobial infections

Approved Indications : Lower respiratory tract infections, Urinary tract infections , Intra-abdominal infections, Gynecological infections, Life-threatening infections (Septicemia, Endocarditis, Shock), Bone and joint infections, Polymicrobial infections

MoA : Envade consists of two components: (1) Imipenem, a derivative of thienamycin, a carbapenem antibiotic; and (2) Cilastatin sodium, a specific inhibitor of dehydropeptidase-I, a renal enzyme which metabolizes and inactivates imipenem. Cilastatin blocks the metabolism of Imipenem in the kidney, so that concomitant administration of Imipenem and Cilastatin allows antibacterial levels of Imipenem to be attained in the urine.

Method of Administration : Each 500 mg dose should be given by intravenous administration over 20 to 30 minutes.

Class : Glycylcycline

Usage : REDACTIS is effective in treating Complicated intra-abdominal Infections, Complicated skin & skin structure infections & Community-acquired Pneumonia.

Approved Indications : Complicated intra-abdominal Infections, Complicated skin & skin structure infections , Community-acquired Pneumonia.

MoA : Tigecycline is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal sub unit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation.

Method of Administration : Intravenous infusion should be administered over approximately 30 to 60 minutes every 12 hours.

Class : Cephalosporins and Beta Lactamase Inhibitors

Usage : Effective in treating Respiratory tract infections (Upper and Lower), Urinary tract infections (Upper and Lower) ,Peritonitis, Cholecystitis, Cholangitis, and Other Intra-abdominal infections. Septicemia, Meningitis , Skin and soft tissue Infections, Bone and joint Infections, Pelvic inflammatory disease, Endometritis, Gonorrhea, and other Infections of the genital tract.

Approved Indications : Respiratory tract infections (Upper and Lower) , Urinary tract infections (Upper and Lower) ,Peritonitis, Cholecystitis, Cholangitis, and Other Intra-abdominal infections. Septicemia, Meningitis , Skin and soft tissue Infections
Bone and joint Infections, Pelvic inflammatory disease, Endometritis, Gonorrhea, and other Infections of the genital tract.

MoA : Cefoperazone, a bactericidal antibiotic, inhibits bacterial cell wall synthesis of actively dividing cells by binding to one or more penicillin binding proteins (PBPs). Sulbactam is a Beta-lactamase inhibitor and acts primarily by irreversible inactivation of Beta -lactamases.

Method of Administration : Each vial of sulbactam/cefoperazone should be reconstituted with the appropriate amount of 5% Dextrose in Water, 0.9% Sodium Chloride Injection or Sterile Water for Injection and then diluted to 20 ml with the same solution followed by administration over 15 to 60 minutes.

Class : Carboxypenicillin & Beta Lactamase Inhibitor

Usage : Ticlawin is effective in treating Septicemia, Lower respiratory infections, Bone and joint infections, Skin and skin structure infections, Urinary tract infections,and Intra-abdominal infections

Approved Indications : Septicemia, Lower respiratory infections, Bone and joint infections, Skin and skin structure infections, Urinary tract infections, Intra-abdominal infections

MoA : Ticarcillin disrupts bacterial cell wall development by inhibiting peptidoglycan synthesis and/or by interacting with penicillin-binding proteins.
Clavulanic acid is produced by the fermentation of Streptomyces clavuligerus. It is a Beta-lactam structurally related to the penicillins and possesses the ability to inactivate a wide variety of Beta-lactamases by blocking the active sites of these enzymes. Clavulanic acid is particularly active against the clinically important plasmid-mediated Beta-lactamases frequently responsible for transferred drug resistance to penicillins and cephalosporins.

Method of Administration : The 3.1-gram vial should be reconstituted by adding approximately 13 mL of Sterile Water for Injection or Sodium Chloride Injection.Â
Intravenous Infusion: The dissolved drug should be further diluted to desired volume using the recommended solution to a concentration between 10 mg/mL to 100 mg/mL. The solution of reconstituted drug may then be administered over a period of 30 minutes.

Class : Cephalosporins

Usage : Zobapime is effective in treating UTI, Febrile neutropenia(FN), Moderate to severe pneumonia, cIAIs, and Uncomplicated SSSI

Approved Indications : UTI, Febrile neutropenia(FN), Moderate to severe pneumonia, cIAIs, Uncomplicated SSSI

MoA : Cefepime -Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs) which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis.
Tazobactam -Tazobactam despite sharing the - lactam - ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Tazobactam to act as a inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics.

Method of Administration : Cefepime+ Tazobactam can be injected as slow IV over 5 Minutes or as an infusion over 30 Minutes.

Class : Cephalosporins

Usage : Zidact is effective in treating Lower Respiratory Tract Infections- including pneumonia, Skin and Skin-Structure Infections, Urinary Tract Infections, both complicated and uncomplicated, Bacterial Septicemia, Bone and Joint Infections, Gynecologic Infections, Intra-abdominal Infections & Central Nervous System Infections

Approved Indications : Lower Respiratory Tract Infections- including pneumonia, Skin and Skin-Structure Infections, Urinary Tract Infections, both complicated and uncomplicated, Bacterial Septicemia, Bone and Joint Infections, Gynecologic Infections, Intra-abdominal Infections, Central Nervous System Infections

MoA : Ceftazidime- Semisynthetic, broad-spectrum antibacterial derived from cephaloridine and used especially for Pseudomonas and other gram-negative infections in debilitated patients.The bactericidal activity of ceftazidime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins
Tazobactam -Tazobactam despite sharing the - lactam - ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Tazobactam to act as a inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics.

Method of Administration : Reconstitute vial with sterile WFI , and further dilute with50ml or 100 ml 0.9 %NaCl, Dextrose 5% , M/6 Sodium Lactate injection & infuse over 30 minutes

Class : Nucleoside, Antiviral

Usage : Mild to Moderate COVID19 Patients,Treatement of Influenza A & B Virus, Ebola virus

Approved Indications : Mild ro Moderate COVID-19 Patients

MoA : The active form, favipiravir-RTP binds to and inhibits the RNA-dependent RNA polymerase (RdRp), preventing viral transcription and replication.Incorporation of favipiravir-RTP into a newly formed RNA strand preventing its elongation and proliferation of the viral genome.
Competitive binding of RNA-dependent RNA polymerase by the favipiravir-RTP and purine nucleosides, which ultimately affects viral replication and transcription.

Method of Administration : Oral Administration, On day 1, 1800mg BID i.e. Morning & Evening 9 tablets respectively. Day2 to Day14 800mg BID i.e.4 tablets Morning & Evening respectively.