Lipid Lowerings

CONVISTAT
Generic Name: ATORVASTATIN IP

 

CONVISTATDescription : CONVISTAT is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3methylglutaryl-coenzyme A to mevalonate, a precursor of sterols, including cholesterol.

CONVISTAT reduces LDL-C in some patients with homozygous familial hypercholesterolemia (FH), a population that rarely responds to other lipid-lowering medication(s).

CONVISTAT reduces total-C, LDL-C, VLDL-C, apo B, TG, and non-HDL-C, and increases HDL-C in patients with isolated hypertriglyceridemia. CONVISTAT reduces intermediate density lipoprotein cholesterol (IDL-C) in patients with dysbetalipoproteinemia.

Indications: Prevention of cardio vascular events in patients with Diabetes Mellitus and /or Metabolic syndrome.

Patient guidance: Patients with hypertension should be advised to inform their healthcare provider if they are pregnant, contemplating pregnancy, breastfeeding, or contemplating breastfeeding.

Storage: Store at 25° C (77° F)

Strengths Available Presentation Brand Name
Atorvastatin 10 mg 10 X 10 tablets CONVISTAT 10
Atorvastatin 20 mg 10 X 10 tablets CONVISTAT 20

 

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STEMATIN
Generic Name: ROSUVASTATIN IP

 

STEMATINDescription : STEMATIN is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzymeA to mevalonate, a precursor of cholesterol.

STEMATIN produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell-surface to enhance uptake andcatabolism of LDL. Second, rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.
Indications: Indicated as adjunctive therapy to diet to reduce elevated Total-C, LDL-C, ApoB, nonHDL-C, and triglycerides and to increase HDL-C in adult patients with primary hyperlipidemia or mixed dyslipidemia.

Patient guidance: Patients with hypertension should be advised to inform their healthcare provider if they are pregnant, contemplating pregnancy, breastfeeding, or contemplating breastfeeding.

Storage: Store at 25° C (77° F)

Strengths Available Presentation Brand Name
Rosuvastatin 5mg 10 X 10 tablets STEMATIN 5
Rosuvastatin 10mg 10 X 10 tablets STEMATIN 10
Rosuvastatin 20mg 10 X 10 tablets STEMATIN 20

 

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STEMATIN F
Generic Name: ROSUVASTATIN IP and FENOFIBRATE

 

STEMATIN FDescription : STEMATIN produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell-surface to enhance uptake andcatabolism of LDL. Second, rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.

It also act by the activation of peroxisome proliferator activated receptor α (PPARα). fenofibrate increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoproteinlipase and reducing production of apoprotein C-III (an inhibitor of lipoprotein lipase activity). The resulting decrease in triglycerides produces an alteration in the size and composition

Indications: Primary hyperlipidemia and mixed dyslipidemia as an adjunct to diet.
Primary dysbetalipoprotenemia as an adjunct to diet.
Homozygous familial hypercholesterolemia.
Atherosclerosis adjunct to diet.

Patient guidance: Patients with hypertension should be advised to inform their healthcare provider if they are pregnant, contemplating pregnancy, breastfeeding, or contemplating breastfeeding.

Storage: Store at 25° C (77° F)

Strengths Available Presentation Brand Name
Rosuvastatin 10mg
+ Fenofibrate 145mg
10 X 10 tablets STEMATIN 10 F

 

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